This mechanism may enable the host to manipulate the gene expression and thereby the behavior of its bacterial colonizers. These results show that an animal manipulates bacterial quorum-sensing signals and that this modification leads to a phenotypic switch in the bacterial colonizers. The College of William & Mary Kaplan Arena 751 Ukrop Way Williamsburg, VA 23185. Liang, Y., Franks, T.M., Marchetto, M.C., Gage, F.H., and Hetzer, M.W. Investigating the impacts of the different N-acyl-HSLs on host colonization elucidated that 3OHC12-HSL allows and 3OC12-HSL represses host colonization of Curvibacter sp. Mazaika, E.J., Vardarajan, B., Italia, M.J., Leipzig, J., et al. Currently a Junior in my 5th semester at ODU. Expression data revealed that Hydra’s main bacterial colonizer, Curvibacter sp., responds differentially to N-(3-hydroxydodecanoyl)- l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)- l-homoserine lactone (3OC12-HSL). Major CyberSecurity Since Fall 2019, expected graduation May 2023 CyberSecurity Webpage. We identified a eukaryotic mechanism that enables Hydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts. Here we show that the early branching metazoan Hydra is able to modify bacterial quorum-sensing signals. Several factors, including the innate immune system, mucus composition, and diet, have been identified as determinants of host-associated bacterial communities. Bacterial communities colonize epithelial surfaces of most animals.
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